Summary: I’ve continued my quest
to find more seminars this week. I also spent time in the OR and ED. Access to patient PACS! Still not able to analyze data.
The first seminar of the week was
the Neurology Grand Rounds and this talk focused on the importance of EEG and
how it can “explain” physical signs when imaging alone cannot, especially the
presence of micro seizures that aren’t present in other imaging modalities. The
reason being is that during deep seizures there is a spike in brain metabolism
that causes a decrease in brain oxygen, which of course can cause irreparable
damage. The second talk focused on
actomyosin in the C. Elegans. Specifically, it was about the spermatheca,
which is a contractile organelle that combines sperm and egg. Its contractile
time line is important in proper zygote formation. Disruption of this timeline
can cause irregularities in 50% of zygotes. The group found the FBAR domain
with a Rho-GAP domain mediates mechanotransduction. They identified PLST-1,
which is enriched in contractile actomyosin and crosslinking by PLST-1 is
needed for cortical contractions to be coordinated. I had a question that asked
if inhibition of PLST-1 could limit migration in cancer cells. Speaker
mentioned that PLST-1 is similar to FBRL-1 in humans and this is an active area
of research.
In the OR, I observed a couple of
Dr. Spector’s cases. Also, observed Dr. Talmor perform a double mastectomy with
skin flap. The most interesting part of the procedure was when the patient was
turned to prone from supine and had a portion of her middle back tissue removed
and passed to the chest region while remaining attached. So the surgeons
created a pocket between the chest and back cavities and passed the vascular tissue
to the chest region and then rolled the patient back over and then closed the pocket.
The patient had previous radiation treatment that caused her skin to be thin
and stiff, so the surgeon had to choose to use tissue expanders instead of
permanent implants.
Currently still dealing with the
IRB issue and not being able to access patient data. Finally, had a break
through and was able to log into the PACS system, but still can’t actually
analyze patient data. Maybe Monday this issue will be resolved and I can analyze
a couple patients before we take off.
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